Semaglutide Effects on Metabolic Outcomes in Diabetes Mellitus Patients - Real World Study.

Purpose: Diabetes is a public health problem that requires strategies to impact glycemic control and reduce the risk of long-term medical complications. Pharmacological management is a necessary treatment for this disease. Therefore, semaglutide is an essential tool to achieve the treatment targets. The present study aimed to evaluate the semaglutide effects on a cohort with type 2 diabetes mellitus (T2DM) in Colombia. Materials and Methods: The cohort included 49 patients with T2DM that have been treated in a specialized care center. Their glycemic outcomes, weight, renal function, and adverse events were evaluated through a 3-, 6- and 12-month follow-up. Results: Significant differences were observed in the outcome evaluation: reduction of glycated hemoglobin levels (MD -2.74 CI -1.95 to -3.52 in 6 months), fasting plasma glucose levels, body weight (MD -7.11 CI -5.97 to -8.24), and the albumin-to-creatinine ratio. The results were maintained throughout the treatment period. The adverse event rate was 16.3%, predominating gastrointestinal events. Conclusion: This real-world evidence shows the efficacy of semaglutide in achieving treatment goals in patients with T2DM.

Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report.

We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response.

Autoimmune Hemolytic Anemia Caused by Cold Agglutinin Antibodies in Systemic Lupus erythematosus-a Rare Association: Case Report.

Autoimmune hemolytic anemias (AIHAs) are rare and heterogeneous disorders characterized by the destruction of red blood cells by warm or cold antibodies. Hemolytic anemia associated with warm antibodies is the most common, whereas cold antibodies are rare and infrequent in cases published in the scientific literature. Herein, we present the case of a young patient with systemic lupus erythematosus (SLE) and autoimmune hemolytic anemia caused by cold antibodies. Initially, infectious etiology and hematological malignancy were considered, which were ruled out. She required management in the intensive care unit due to severe hematological involvement and responded well to immunomodulatory therapy. This case illustrates the importance of a strong clinical suspicion of AIHA due to cold agglutinins associated with SLE when faced with similar clinical symptoms in order to achieve a timely diagnosis and provide optimal therapy.

First case report of tumor lysis syndrome after third line systemic therapy with gemcitabine and pazopanib in a patient with lower extremity soft tissue sarcoma.

BACKGROUND: Tumor lysis syndrome (TLS) is recognized as an oncologic disorder with a variable incidence. TLS can cause the rapid destruction of tumor cells in response to oncologic therapy and is characterized by multiple electrolyte disturbances as well as its secondary complications, including death. This disease is common among patients with hematologic neoplasms, but very rare among those with solid tumors, as is the case with sarcomas. Such patients have a poor prognosis and increased risk of mortality. In the patient's particular case, this occurred after initiating third-line systemic therapy with gemcitabine associated with pazopanib, an event not previously described in the literature. CASE DESCRIPTION: We report the case of a patient with a history of high-grade sarcoma of the left lower limb T4N1M0 stage IIIB undergoing surgical management and exhibiting tumor progression with the need for third-line systemic therapy with pazopanib and gemcitabine. The patient presented with pain at the amputation site, inflammatory changes, and a tumor mass of large components on admission. They later developed electrolyte imbalance and acute renal injury compatible with TLS after systemic therapy was initiated. Pharmacological therapy, including rasburicase, was initiated based on the clinical and laboratory findings. Due to the progression of renal involvement, it was necessary to initiate haemodialysis, and during her hospital stay, the patient presented febrile syndrome associated with pancytopenia. The patient showed a favourable clinical response to the proposed antibiotic therapy and recovery of renal function, for which reason therapy was restarted with pazopanib and gemcitabine, the latter with a 20% reduction for the following cycles. Outpatient follow-up continued, completing eight cycles of treatment with good tolerance and partial clinical response; the patient died of respiratory complications eight months after discharge. CONCLUSIONS: There is limited evidence for TLS in patients with high-grade sarcoma in the literature related to the oncologic therapy used; this indicates that early risk evaluation along with prompt initiation of effective therapies is required to prevent the appearance of this type of complications in the short and long term.

Pulmonary Thromboembolism in Pregnancy: A Case Report and Literature Review.

Data on the optimal diagnostic management of pregnant women with suspected pulmonary embolism are limited. Despite a lack of compelling evidence in some practices, clinical practice guidelines focus on the management of these patients. We present the case of a 24-year-old patient at 36 weeks of pregnancy in whom pulmonary thromboembolism (PTE) was diagnosed in a timely manner also with hemodynamic instability and echocardiographic images with clear involvement of the right cavities. She received thrombolytic therapy with alteplase 100 mg intravenously over 2 hours, which resulted in excellent outcomes for both the pregnant woman and fetus. Understanding the acute approach and management of these patients will improve our clinical practice; therefore, we reviewed a case report of a pregnant patient with high-risk PTE and compared it with current evidence. In conclusion, PE is a common disease with a high mortality rate during pregnancy. Therefore, having made a timely diagnosis using the relevant diagnostic aids and performing thrombolysis with rtPA increase the probability of survival in our patient, leading to successful results for both her and the fetus.

Frequent Cardiovascular Manifestations Associated With SARS Cov-2 Infection: Experience at a Tertiary Hospital In Cali, Colombia

Abstract Background: Coronavirus disease 2019 (COVID-19) mainly affects the respiratory system, while the most common extrapulmonary complication of COVID-19 is cardiovascular involvement. Objective: To identify the frequency of electrocardiographic changes and cardiac arrhythmias in patients hospitalized with COVID-19 infection. Methods: This was a cross-sectional study, including patients aged >18 years with diagnosis of severe acute respiratory syndrome coronavirus 2 infection in a high-complexity hospital in Santiago de Cali, Colombia, from March to September 2020. A descriptive analysis with an analytical component and multiple logistic regression analysis were performed; all estimates were established with a 95% confidence level (CI) and a 5% significance level. Results: This study included 183 individuals; of whom 160 were considered for electrocardiographic analysis, 63% of which evidenced significant findings, the most frequent being sinus tachycardia (29.4%). The frequency of myocardial injury was 21.9% and was more common among non-survivors than among survivors (41.7% vs. 12.2%, p < 0.001). Myocardial injury was also significantly more common in patients who presented electrocardiographic findings than those who did not (26.5% vs. 12.1%, p = 0.032) and in those who required intensive care admission (31.8% vs 10.5%, p < 0.001). The strongest mortality-associated factor was the need for mechanical ventilation — odds ratio (OR), 9.14; 95% confidence interval, 3.4-24.5. Conclusions: Electrocardiographic findings in patients with COVID 19 are frequent, including newly diagnosed arrhythmias, justifying the use of cost-effective tools for the initial approach and follow-up of this affected population. Worse outcomes depend on factors such as invasive mechanical ventilation, comorbidities, age, and superinfection.

Prevalence of Anti-SARS-CoV-2 Antibodies and Associated Factors Among Health Care Workers in Santiago De Cali, Colombia.

Purpose: This study aims to determine the seroprevalence of coronavirus disease (COVID-19) among health care workers and describe the associated sociodemographic and labor features. Patients and Methods: An observational study with an analytical component was conducted at a clinic in Cali, Colombia. The sample size was 708 health workers and they were selected by stratified random sampling. A Bayesian analysis was developed to determine the raw and adjusted prevalence. A Poisson regression model was used to estimate the prevalence ratios. Results: Overall seroprevalence of COVID-19 among healthcare workers was 29%. Miscellaneous services workers, healthcare, and administrative workers, was 38%, 33%, and 32%, respectively. Factors related to seropositivity were having a contact with a COVID-19 patient for >120 minutes and being diagnosed with COVID-19 by laboratory tests. Conclusion: The present study shows a adjusted seroprevalence of 29% in health workers, indicating a high level of disease transmission and an increased risk of infection in this population group.

Effects of a Physical Exercise Program on the Physical Capacities of Older Adults: A Quasi-Experimental Study.

Purpose: To measure the effects of an exercise program on the physical capacities of older adults such as strength, flexibility, balance, and aerobic capacity. Patients and Methods: This was a quasi-experimental study on a population of 5550 older adults and a sample of 4830 participants in an active aging program designed by the Municipal Health Secretary. The exercise program lasted 12 months, and pre-and post-program intervention measures were recorded using the senior fitness test. Results: Most participants were women (92.4%) and their mean age was 70.7 years (standard deviation, 7.3 years; range, 60-97 years). All areas showed significant differences before and after the program in terms of the participants' physical capabilities (p < 0.05), muscular strength and flexibility had a more significant mean difference and a large effect (>0.80), except for aerobic capacity, which had a small effect. Conclusion: The present study revealed that a supervised physical exercise program at the community level has positive effects on the physical capacities of coordination, balance, flexibility, strength, and aerobic capacity, which are essential components for a better functional capacity at this stage of life, with improvements that encompassed the improved self-perception of their health status, a reduction of overweight and obesity. The reinforcement of these programs is recommended, consequently, promoting pre-sport games and sports championships among the elderly population, as a public health strategy.

Prolonged Mechanical Ventilation Following Coronary Artery Bypass Graft in Santiago De Cali, Colombia.

Purpose: The purpose of this study was to describe factors associated with prolonged ventilatory support in subjects undergoing coronary artery bypass graft. Patients and Methods: This was an analytical retrospective case-control study. Cases were defined as subjects requiring prolonged mechanical ventilation (>48 hours) following isolated coronary artery bypass graft. Subjects older than 18 years who had undergone surgery were included, while subjects with missing clinical record data, subjects in coma or subjects with prior cardiac surgery were excluded. Variables were measured at the three time points surrounding surgery. Results: A total of 204 cases and 408 controls were included. The final logistic model showed an association between prolonged mechanical ventilation and the following presurgical variables: chronic obstructive pulmonary disease (OR 1.85; 95% CI: 1.06-3.23, p = 0.03) and chronic kidney disease (OR 1.90; 95% CI: -3.31; p = 0.02). The associated transurgical variable was the use of intra-aortic balloon pump (OR 3.63; 95% CI: 1.73-7.61, p = 0.00), and associated postsurgical variables were venous oxygen saturation <60% (OR 2.00; 95% CI: 1.18-3.40, p = 0.01), mediastinitis (OR 18.51; 95% CI: 4.06-84.40, p = 0.00), inotrope use (OR 2.82; 95% CI: 1.77-4.48, p = 0.00), pleural effusion requiring drainage (OR 3.57; 95% CI: 2.02-6.32, p = 0.00) and delirium (OR 3.45; 95% CI: 1.91-6.25, p = 0.00). Conclusion: This study identifies factors associated with prolonged mechanical ventilation in subjects subject to coronary artery bypass graft over the presurgical, transurgical and postsurgical periods, identifying a new factor, delirium, for this type of population.

Effects of muscle energy technique for quadratus lumborum on respiratory muscle strength in patients with breast cancer / Efectos de la técnica de energía muscular del cuadrado lumbar sobre la fuerza muscular respiratoria en pacientes con cáncer de mama

Abstract Introduction: Breast cancer is a major cause of morbidity and mortality, leading to functional deficiencies in ventilation, muscle performance, balance and posture. Objective: To describe the effects of the muscle energy technique (MET) for quadratus lumborum on maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in patients with stage I and II breast cancer. Materials and methods: Quasi-experimental study with a pretest-posttest design conducted in 10 patients treated at a highly specialized healthcare center in Bogotá. Physical therapy assessment and three physiotherapy sessions with the MET to measure MIP and MEP were carried out before and after the intervention using a respiratory pressure meter. Results: The average MIP was 41% of the reference value at the beginning of the intervention, which increased to 69% at the end of the sessions. On the other hand, the initial average MEP was 33%, while the post-intervention average MEP was 51%. The average change rate for MIP was 68% and 57% for MEP. The Wilcoxon signed-rank test was performed, achieving a statistically significant difference (z=-2.807, p=0.005). Conclusion: Applying the MET on the quadratus lumborum muscle improves its performance and increases respiratory muscle strength.

Resumen Introducción. El cáncer de mama constituye una importante causa de morbimortalidad y genera deficiencias funcionales en la ventilación, el desempeño muscular, el balance y la postura. Objetivo. Describir los efectos de la técnica de energía muscular (TEM) del cuadrado lumbar sobre la presión inspiratoria (PIM) y espiratoria máxima (PEM) en pacientes con cáncer de mama en estadios I y II. Materiales y métodos. Estudio cuasiexperimental tipo pre-test/post-test realizado en 10 pacientes atendidas en una institución de salud de alta complejidad de Bogotá D.C., Colombia. Se realizó valoración fisioterapéutica y tres sesiones de fisioterapia con la TEM midiendo PIM y PEM antes y después de la intervención con medidor de fuerza respiratoria. Resultados. El promedio de la PIN al inicio de la intervención fue de 41% y al final de 69%, mientras que el de la PEM fue de 33% y 51%, respectivamente. La media de la proporción de cambio en la PIM fue de 68% y en la PEM de 57%. Se realizó la prueba estadística de signo-rango de Wilkoxon, logrando determinar una diferencia estadísticamente significativa (z=-2.807, p=0.005). Conclusión. La TEM mejora el desempeño del músculo cuadrado lumbar e incrementa la fuerza muscular respiratoria.

Síndromes asociados a intoxicación por organofosforados: abordaje médico y fisioterapéutico en cuidado crítico / Syndromes Associated with Organophosphate Poisoning: Medical and Physiotherapy Approach in Critical Care / Síndromes associados a intoxicação por organofosforados: abordagem médica e fisioterapêutica em cuidado crítico

Resumen Introducción: El artículo reporta un caso clínico de intento suicida de un paciente con síndrome intermedio a causa de intoxicación por organofosforados. Para ello se analizó la historia clínica, los exámenes complementarlos y el estudio electromiográflco, y se realizó revisión no sistemática de la literatura. Presentación del caso: Se describe un caso diagnosticado en la unidad de cuidado intensivo, el cual presentó trastornos neuromotores, requerimiento de soporte ventilatorio con destete difícil y extubación fallida, así como el tratamiento médico y fisioterapéutico instaurado. Dentro del manejo de la intoxicación por organo-fosforados se incluye la descontaminación del tóxico, administración de atropina y pralidoxima, diagnóstico oportuno del síndrome intermedio y la prescripción de ejercicio terapéutico. El paciente recibió manejo interdisciplinario, logrando liberación de su condición crítica, pero con persistencia de debilidad muscular proximal; sin embargo, con el ejercicio alcanzó recuperación funcional de sus actividades básicas cotidianas. Conclusión: El panorama mundial de las intoxicaciones por sustancias químicas muestra que son causa de morbilidad y discapacidad importante. Los organofosforados son los plaguicidas más frecuentemente involucrados. Los síntomas y signos clínicos de este tipo de intoxicaciones se clasifican en manifestaciones colinérgicas, el síndrome intermedio y la neuropatía retardada.

Abstract Introduction: The article reports a clinical case of a suicide attempt of a patient with intermediate syndrome due to organophosphate poisoning. Researchers analyzed the clinical history and the complementary examinations and carried out an electro-myographic study and a non-systematic review of the literature. Case presentation: A diagnosed case is described in the unit of intensive care, which presented neuro-motor disorders, required ventilator support with difficult weaning and unsuccessful extubation, as well as the established medical and physiotherapeutic treatment. The management of organophosphate poisoning includes the decontamination of the toxic, the administration of atropine and pralidoxime, the diagnosis of the intermediate syndrome, and the prescription of therapeutic exercise. The patient received interdisciplinary management, achieving liberation from his critical condition but with the persistence of proximal muscular weakness; however, with the exercise, he accomplished functional recovery for basic daily activities. Conclusion: The global outlook of chemical substances poisoning shows that they are a cause of morbidity and significant disability. The organophosphates are the pesticides most frequently involved. The symptoms and the clinical signs of this type of intoxication are classified into cholinergic manifestations, intermediate syndrome, and delayed neuropathy.

Resumo Introdução: O artigo reporta um caso clínico de tentativa suicida de um paciente com síndrome intermeio a causa de intoxicação por organofosforados. Para isto, analisara-se história clínica, os exames complementários e o estudo eletromiográfico, e se realizou revisão não sistemática da literatura. Apresentação do caso: Descreve-se um caso diagnosticado na unidade de cuidado intensivo, o qual apresentou transtornos neuromotores, requerimento de suporte ventilatório com desmame difícil e extubação falhada, tanto como o tratamento médico e fisioterapéutico instaurado. Dentro do manejo da intoxicação por organofosforados se inclui a descontaminação do tóxico, administração de atropina e pralidoxima, diagnóstico oportuno da síndrome intermeia e a prescrição de exercício terapêutico. O paciente recebeu manejo interdisciplinar, conseguindo liberação de sua condição crítica, mas com persisténcia de debilidade muscular proximal; no entanto, com o exercício alcançou recuperação funcional de suas atividades básicas cotidianas. Conclusão: O panorama mundial das intoxicações por substâncias químicas mostra que são causa de morbilidade e deficiência importante. Os organofosforados são os pesticidas mais frequentemente envolvidos. Os sintomas e signos clínicos deste tipo de intoxicações classificam-se em manifestações colinérgicas, a síndrome intermeia e a neuropatia retardada.

Factores estresores y síntomas somáticos del sistema musculoesquelético en estudiantes universitarios de Palmira / Stress-producing factors and somatic symptoms of the musculoskeletal systems of University Students of Palmira

Introducción: En el mundo uno de cada cuatro individuos sufre de algún problema grave de estrés y en las ciudades se estima que el 50 por ciento de las personas tienen algún problema de salud mental de este tipo. En este sentido, como factor epidemiológico se considera un aspecto de gravedad, ya que el estrés es un importante generador de diversas patologías. Objetivo: Identificar los factores estresores y síntomas somáticos del sistema musculoesquelético en estudiantes de básicas pertenecientes a diversos programas de una facultad de salud en una universidad de la ciudad de Palmira. Métodos: Se analizaron datos procedentes de tres fuentes: un cuestionario para identificar características sociodemográficas y académicas, la Escala de Síntomas Somáticos (síntomas musculoesqueléticos) y la Escala de Estresores Académicos, estos se aplicaron a muestra conformada por 185 participantes realizando análisis estadístico descriptivo e inferencial. Resultados: Las deficiencias metodológicas del profesorado, la intervención en público y los exámenes, fueron los factores estresores frecuentemente percibidos por los estudiantes; mientras que: los dolores de espalda, zona cervical y cabeza con sensación de tirantez, fueron los síntomas somáticos musculoesqueléticos de mayor periodicidad. Estos resultados sugieren una relación entre los factores estresores y la presencia de somatización como respuesta del cuerpo a situaciones consideradas estresores en el ámbito académico. Conclusiones: De acuerdo a los síntomas somáticos músculos esqueléticos se evidencia una variabilidad en la incidencia en la población a estudio, siendo los más recurrentes los dolores de cabeza con sensación tirantez o tensión, dolores de espalda y dolores en la nuca o zona cervical. Ahora bien, en cuanto a los factores estresores que les genera más percepción de angustia a los estudiantes son las deficiencias metodológicas del profesorado, la intervención en público y los exámenes. Sin embargo, hay otros factores con mediana percepción de angustia como la sobrecarga en el estudiante y la falta de control en rendimiento(AU)

Introduction: One out of every four individuals in the world suffers from a serious stress condition. 50 percent of people living in the cities are estimated to have some kind of mental health problem of this type. In this respect, as an epidemiological factor, stress is considered a serious element, since it is an important generator of various pathologies. Objective: To identify the stress-producing factors and somatic symptoms of the musculoskeletal system in basic students belonging to various programs of a health school at a university in the city of Palmira. Methods: We analyzed data from three sources: a questionnaire to identify sociodemographic and academic characteristics, the Somatic Symptoms Scale (musculoskeletal symptoms) and the Academic Stress Scale. These were applied to a sample consisting of 185 participants, performing descriptive and inferential statistical analysis. Results: The faculty methodological deficiencies, together with public intervention and the exams were the stressors frequently perceived by the students, while back pain, cervical area and head with feeling of tightness were the most frequent somatic musculoskeletal symptoms. These results suggest a relationship between stressors and the presence of somatization as a response of the body to situations considered stressful in the academic field. Conclusions: Regarding somatic and musculoskeletal symptoms, there is a variability in the incidence in the study population, the most recurrent being headaches with tightness or tension, back pain and pain in the cervical area. However, the stressors that generate more perception of distress to students are the methodological deficiencies of the faculty, public intervention and exams. However, there are other factors with a medium perception of distress such as overload in the student and lack of performance control(AU)

Prevalencia de sintomáticos respiratorios y factores relacionados en dos territorios vulnerables de santiago de cali / Prevalence of symptomatic respiratory disease and related factors in two vulnerable territories of santiago de cali / Prevalência de sintomático respiratório e fatores relacionados em dois territorios vulneraveís de santiago de cali

OBJETIVO: Estimar la prevalencia poblacional de sintomáticos respiratorios y los factores relacionados en los residentes de dos territorios vulnerables de la ciudad Santiago de Cali en el año 2012. MATERIALES Y MÉTODOS: Estudio descriptivo de corte transversal con componente analítico que simula la metodología tipo casos y controles. Utilizó un muestreo estratificado por conglomerados, con efecto de diseño de 2. Se realizó un análisis univariado, bivariado y múltiple a partir de regresión logística con análisis de muestras complejas para estimación de las asociaciones, se utilizó la razón odds ratio con sus respectivos intervalos de confianza y el valor de p de la prueba Chi2. Para evaluar el ajuste del modelo final, se aplicó la prueba de bondad de ajuste de Hosmer y Lemeshow. RESULTADOS: La prevalencia de sintomáticos respiratorio global fue de 2,8% (IC95%: 2,2-3,6). Se evidenció como factor de riesgo ser hombre (OR 1,51, IC95%: 1,06-2,17), residir en una vivienda con ventilación no adecuada (OR 1,97, IC95%: 1,27-3,06) y hogares con inseguridad alimentaria con hambre moderada (OR 1,63, IC95%: 1,15-2,31). Como factores protectores se identificaron aseguramiento (OR 0,41, IC95%: 0,19-0,89), ser lactante (OR 0,60, IC95%: 0,37-0,98), preescolar (OR 0,46, IC95%: 0,23-0,93), adulto maduro (OR 0,34, IC95%: 0,17-0,68) y mayor (OR 0,45, IC95%: 0,27- 0,77), respecto a los adolescentes. CONCLUSIONES: La prevalencia poblacional de sintomáticos respiratorios es diferencial de acuerdo con las condiciones de vulnerabilidad de la población, lo que implica generar indicadores programáticos en coherencia con este resultado

OBJECTIVE: To estimate the population prevalence of symptomatic respiratory disease and related factors in residents of two vulnerable areas in the city of Santiago de Cali in 2012. METHODS: Descriptive cross-sectional study with an analytical component that simulates the case-control methodology. A stratified sampling by conglomerates was used, with design effect 2. Univariate bivariate and multiple analyses were performed from logistic regression with analysis of complex samples. The odds ratio with their respective intervals of confidence and p-value of the Chi2 test were used to estimate the associations. To evaluate the fit of the final model, Hosmer and Lemeshow goodness of fit testing was applied. RESULTS: The overall population prevalence of symptomatic respiratory disease was 2.8% (CI 95% 2.2 to 3.6). Being a male (OR 1.51, CI 95%: 1.06 to 2.17), living in a house without proper ventilation (OR 1.97, CI 95%: 1.27 to 3.06) and food-insecure households with moderate hunger (OR 1.63, CI 95%: 1.15 to 2.31) were shown as a risk factors. Assurance (OR 0.41, CI 95%: 0.19 to 0.89), being a breastfed baby (OR 0.60, CI 95%: 0.37 to 0.98), being a preschooler (OR 0.46, CI 95%: 0.23 to 0.93), being a mature adult (OR 0.34, CI 95%: 0.17 to 0.68) and being elder (OR 0.45, CI 95%: 0.27 to 0.77) compared to adolescents were identified as protective factors. CONCLUSIONS: population prevalence of symptomatic respiratory disease is differential according to the vulnerability conditions of the population, which implies generating programmatical indicators consistent with this result

OBJETIVO: Avaliar a prevalência na povoação os sintomáticos respiratórios e os fatores relacionados nos residentes de dois territórios vulneráveis da cidade Santiago de Cali em o ano 2012. MATERIAIS E MÉTODOS: Estudo Descritivo de corte transversal com componente analítico que simula a metodologia tipo de casos e controles. Utilizou uma amostragem estratifico por conglomerados, com efeito de desenho de 2. Realizou se uma analise univariado, bivariado e múltiplo a partir de regressão logística com analise de amostras complexas para estimação das associações, utilizou se a razão odds ratio com seus respectivos intervalos de confiança e o valor de p da prova Chi2. Para avaliar o ajuste do modelo final, se aplicou o teste de bondade de ajuste de Hosmer e Lemeshow. RESULTADOS: a prevalência de sintomas respiratórios global foi de 2,8% (IC95%: 2,2-3,6). Evidenciou se como fator de risco for home (OR 1,51, IC95%: 1,06-2,17), (OR 1,51, IC95%: 1,06-2,17), residir em uma morada com ventilação não adequada (OR 1,97, IC95%: 1,27-3,06) e lares com insegurança alimentaria com fome moderada residir em uma morada com ventilação não adequada (OR 1,97, IC95%: 1,27-3,06) e lares com insegurança alimentaria com fome moderada (OR 1,63, IC95%: 1,15-2,31). Como fatores protetores se identificaram a salvaguarda (OR 0,41, IC95%: 0,19-0,89), ser lactante (OR 0,60, IC95%: 0,37-0,98), pré-escolar (OR 0,46, IC95%: 0,23-0,93), adulto maduro (OR 0,34, IC95%: 0,17-0,68) e maior (OR 0,45, IC95%: 0,27-0,77), respeito aos adolescentes. CONCLUSÕES: A prevalência na povoação de sintomáticos respiratórios é diferencial de acordo com as condições de vulnerabilidade da povoação, o que implica gerar indicadores programáticos em coerência com este resultado